Tongue cancer is a type of oral cancer that begins in the cells of the tongue. It is often grouped under head and neck cancers and can significantly impact a person’s ability to speak, eat, and swallow. Early detection and treatment are crucial for improving outcomes. In this article, we will explore the causes, symptoms, and treatments of tongue cancer to help you better understand this condition.

Tongue Cancer: Understanding Causes, Symptoms, and Treatments

What is Tongue Cancer?

Tongue cancer occurs when malignant cells form in the tissues of the tongue. There are two primary types of tongue cancer:

  • Oral Tongue Cancer: This type affects the front two-thirds of the tongue, which is part of the oral cavity.
  • Oropharyngeal Tongue Cancer: This type develops in the back one-third of the tongue, which is located in the oropharynx.

Both types share similar characteristics but may differ in terms of risk factors, symptoms, and treatment approaches.

Causes of Tongue Cancer

The exact cause of tongue cancer is not fully understood, but several factors have been identified as potential contributors. These include:

Tobacco Use

Smoking cigarettes, cigars, or pipes, as well as chewing tobacco, significantly increases the risk of developing tongue cancer. Tobacco contains harmful chemicals that can damage the cells in the mouth and lead to cancerous growths.

Alcohol Consumption

Heavy alcohol use is another major risk factor for tongue cancer. When combined with tobacco use, the risk becomes even greater. Alcohol can irritate the cells in the mouth and throat, making them more susceptible to cancer.

Human Papillomavirus (HPV)

HPV is a group of viruses that can infect the skin and mucous membranes. Certain strains of HPV, particularly HPV-16, have been linked to an increased risk of oropharyngeal tongue cancer. Unlike other risk factors, HPV-related tongue cancer tends to occur in younger individuals who may not have a history of tobacco or alcohol use.

Poor Oral Hygiene

Neglecting oral health can lead to chronic irritation and inflammation in the mouth, which may increase the likelihood of cancer development. Regular dental checkups and good oral hygiene practices are essential for reducing this risk.

Dietary Factors

A diet low in fruits and vegetables and high in processed meats has been associated with a higher risk of oral cancers, including tongue cancer. Nutrients found in fruits and vegetables, such as vitamins A, C, and E, play a protective role in maintaining healthy tissues.

Chronic Irritation

Long-term irritation from poorly fitting dentures, jagged teeth, or other oral conditions can damage the cells in the tongue and contribute to cancer formation.

Symptoms of Tongue Cancer

Recognizing the symptoms of tongue cancer early can improve the chances of successful treatment. Common signs and symptoms include:

Persistent Sores or Ulcers

One of the most noticeable symptoms of tongue cancer is the presence of sores or ulcers on the tongue that do not heal within two weeks. These sores may bleed easily and cause discomfort.

Pain or Difficulty Swallowing

Individuals with tongue cancer may experience pain while swallowing or feel as though food is getting stuck in their throat. This symptom can interfere with eating and drinking, leading to weight loss and malnutrition.

Lumps or Thickening on the Tongue

A lump or thickened area on the tongue can indicate abnormal cell growth. This may be accompanied by changes in texture or color, such as white or red patches.

Numbness or Tingling

Some people with tongue cancer report numbness or tingling sensations in the tongue or mouth. This occurs when cancer affects the nerves in the affected area.

Voice Changes

Cancer in the back of the tongue can affect the voice, causing hoarseness or other changes in speech. This symptom is more common in cases of oropharyngeal tongue cancer.

Ear Pain

Although tongue cancer does not directly involve the ear, some patients experience referred pain in the ear due to the proximity of the nerves in the tongue and throat.

Diagnosis of Tongue Cancer

If tongue cancer is suspected, a healthcare provider will perform a series of tests to confirm the diagnosis. These may include:

Physical Examination

A thorough examination of the mouth, throat, and neck is typically the first step. The doctor will look for visible abnormalities, such as sores, lumps, or discoloration, and assess the overall health of the oral cavity.

Biopsy

A biopsy involves removing a small sample of tissue from the suspicious area for laboratory analysis. This test determines whether cancer cells are present and helps classify the type of cancer.

Imaging Tests

Imaging techniques such as X-rays, CT scans, MRI scans, or PET scans may be used to evaluate the extent of the cancer and determine if it has spread to nearby lymph nodes or other parts of the body.

Endoscopy

An endoscope, a thin tube with a camera attached, may be inserted through the nose or mouth to examine the throat and surrounding areas. This procedure provides a detailed view of hard-to-reach regions.

Treatment Options for Tongue Cancer

The treatment plan for tongue cancer depends on various factors, including the stage of the cancer, its location, and the patient’s overall health. Common treatment options include:

Surgery

Surgical removal of the tumor is often the first line of treatment for early-stage tongue cancer. Depending on the size and location of the tumor, different surgical techniques may be employed:

  • Partial Glossectomy: Removal of part of the tongue.
  • Total Glossectomy: Removal of the entire tongue, which is rare and only considered in advanced cases.
  • Neck Dissection: Removal of lymph nodes in the neck to check for cancer spread.

Reconstructive surgery may be necessary after extensive procedures to restore function and appearance.

Radiation Therapy

Radiation therapy uses high-energy beams to target and destroy cancer cells. It may be used alone for early-stage cancers or in combination with surgery and chemotherapy for more advanced cases. Side effects can include dry mouth, difficulty swallowing, and changes in taste.

Chemotherapy

Chemotherapy involves the use of drugs to kill cancer cells. It is often administered intravenously and may be combined with radiation therapy to enhance effectiveness. Chemotherapy can cause side effects such as nausea, hair loss, and fatigue.

Targeted Therapy

Targeted therapy focuses on specific molecules involved in cancer growth. For example, drugs that block the activity of certain proteins can slow or stop the progression of HPV-related tongue cancer. This approach is less toxic than traditional chemotherapy.

Immunotherapy

Immunotherapy harnesses the body’s immune system to fight cancer. Drugs known as checkpoint inhibitors can help the immune system recognize and attack cancer cells. This treatment is particularly effective for advanced or recurrent tongue cancer.

Living with Tongue Cancer

A diagnosis of tongue cancer can be life-changing, but many individuals continue to lead fulfilling lives with appropriate care and support. Here are some tips for managing the condition:

Follow-Up Care

Regular follow-up appointments are essential to monitor recovery and detect any recurrence of cancer. These visits may include physical exams, imaging tests, and blood work.

Speech and Swallowing Therapy

After treatment, some patients may require therapy to regain their ability to speak and swallow. Speech-language pathologists can provide exercises and strategies to improve these functions.

Nutritional Support

Maintaining proper nutrition is critical during and after treatment. A dietitian can help create a meal plan that meets individual needs and addresses challenges such as difficulty swallowing.

Emotional Support

Dealing with cancer can take an emotional toll. Joining a support group or seeking counseling can help patients and their families cope with the psychological aspects of the disease.

Prevention of Tongue Cancer

While not all cases of tongue cancer can be prevented, adopting certain lifestyle changes can reduce the risk:

  • Avoid tobacco products entirely.
  • Limit alcohol consumption or abstain altogether.
  • Practice good oral hygiene and visit the dentist regularly.
  • Eat a balanced diet rich in fruits and vegetables.
  • Get vaccinated against Human Papillomavirus if eligible.
  • Protect the lips and mouth from excessive sun exposure.

Categorized in:

Condition, Oncology, Otolaryngology,

Last Update: June 20, 2025